姓名：王怡 职称：副教授/硕士研究生导师（学术型）

学历：博士研究生 学位：博士 Ph. D.

个人简介

2005年毕业于华中科技大学同济医学院公共卫生学院流行病与卫生统计学专业，获得硕士学位。同年进入温州医学院预防医学系从事教学与科研工作。2013-2014年于美国梅奥医学中心（Mayo Clinic）流行病学系进行访学，师从Ping Yang教授。2017年获得温州医科大学博士学位。现为新葡的京集团350vip8888临床流行病学与循证医学研究中心副主任；美国梅奥医学中心流行病学习特约合作研究员；美国癌症研究协会（AACR）会员；中国药学会药物流行病学专业委员会青年委员会常务委员；浙江省医学会临床流行病学与循证医学专业委员会青年委员会委员；《药物流行病学杂志》青年编委。

专业

流行病与卫生统计学

主要研究方向

临床流行病学；慢性非传染性疾病流行病学；肿瘤流行病学；生物信息与统计学；药物流行病学

主持及参与的科研项目

1.国家自然科学基金青年项目（81703310），SCUBE1调控Shh/SMO/Gli1信号通路在肝癌细胞干性转化与恶性进程中的作用及其预后预测研究，2018/01-2020/12，主持

2.浙江省科技厅（2018C37114），SCUBE1 基因在肿瘤相关成纤维细胞促肝癌干性转化过程中的作用及其机制分析，2018/01-2020/12，主持

3.国家自然科学基金面上项目（81772628），转移前微环境中Periostin/CCL2/CD36信号轴促肝癌转移起始细胞形成的分子机制研究，2018/01-2021/12，主要参与人

4.国家自然科学基金青年项目（81201953），EphA1/EphrinA1通路调控EPCs归巢肝癌新生血管的分子机制研究，2013/01-2015/12，主要参与人

5.浙江省教育厅（Y201120049），EphrinA1及其受体基因与环境因素对肝癌发病影响的流行病学研究，2011/06-2013/05，主持

代表性论文

Yi Wang, David E Midthun, Jason A Wampfler, Bo Deng, Shawn M Stoddard, Shuo Zhang, Ping Yang*, Trend in the proportion of patients with lung cancer meeting screening criteria, JAMA, 2015, 313(8):853-855 (JCR一区，IF: 44.4)

第一或者共同第一作者发表论文

(1)Yi Wang^#, Haitao Yu^#, Yunfeng Shan, Chonglin Tao, Fang Wu, Zhengping Yu, Pengyi Guo, Jianfei Huang, Junjian Li, Qiandong Zhu, Fuxiang Yu, Qitong Song, Hongqi Shi, Mengtao Zhou*, Gang Chen*. EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway, Journal of Experimental & Clinical Cancer Research,2016,35:65 (JCR一区，IF:6.2 )

(2)Pengyi Guo^#, Yi Wang^#,,Chunxiu Dai, Chonglin Tao, Fang Wu, Xiaozai Xie, Haitao Yu, Qiandong Zhu, Junjian Li, Longyun Ye, Fuxiang Yu, Yunfeng Shan, Zhengping Yu, Renumathy Dhanasekaran, Rongyuan Zheng, Gang Chen*. Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma. Oncogene. 2018, 37(9):1220-1236(JCR一区，IF:7.5)

(3)Brid M Ryan^#,Yi Wang^#, Jin Jen, Eunhee S Yi, Susan Olivo-Marston, Ping Yang, Curtis C Harris*, Evidence that the lung adenocarcinoma EML4-ALK fusion gene is not caused by exposure to secondhand tobacco smoke during childhood, Cancer Epidemiol Biomarkers Prev, 2014, 23(7):1432-1434（JCR二区，IF:4.1）

(4)Maiyu Xu^#, Yi Wang^#, Lei Chen,Bujian Pan,Feng Chen,Yang Fang, Zhengping Yu,Gang Chen*, Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro, Gene,2014, 536(1):84-89 （JCR三区，IF:2.4）

(5)Bo Deng ^#, Yi Wang^#, Dong Xie, Shawn M. Stoddard, Ping Yang*, Metformin use and young age lung cancer: A case series report, Oncology letters, 2016,11:2899-2902（JCR四区，IF:1.4）

署名论文

(1)Li Q, Zhang P, Wang Y, Liu D, Luo L, Diasio R, Yang P, Jiang G. T4 extension alone is more predictive of better survival than a tumour size >7 cm for resected T4N0–1M0 non-small-cell lung cancer. Eur J Cardiothorac Surg. 2018; doi:10.1093/ejcts/ezy360

(2)Chen Z, Guo P, Xie X, Yu H, Wang Y, Chen G. The role of tumour microenvironment: a new vision for cholangiocarcinoma. J Cell Mol Med. 2018; 00:1-11. doi:10.1111/jcmm.13953

(3)Gang Chen, Huajun Yu, Yi Wang, Chenhao Li, Mengtao Zhou, Zhengping Yu, Xiangwu Zheng, Xiuling Wu, Yunfeng Shan, Qiyu Zhang, Qiqiang Zeng*, A novel nomogram for the prediction of intrahepatic cholangiocarcinoma in patients with intrahepatic lithiasis complicated by imagiologically diagnosed mass, Cancer Management and Research, 2018,10: 847-856

(4)Xiaozai Xie, Pengyi Guo, Haitao Yu, Yi Wang, Gang Chen*, Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma, Oncogene,2018, 37(3):277-285

(5)Lin J, Wang X, Dong F, Du Y, Shen J, Ding S, Wang L, Ye M, Wang Y, Xia N, Zheng R, Chen H, Xu H. Validation of the Chinese version of the Hamilton Rating Scale for Depression in adults with epilepsy. Epilepsy & Behavior. 2018;89: 148–152

(6)Haitao Yu, Pengyi Guo, Xiaozai Xie, Yi Wang, Gang Chen*, Ferroptosis, a new form of cell death, and its relationships with tumourous diseases, J Cell Mol Med, 2017,21(4):648-657

(7)Chang XC, Yuan H, Wang Y, Xu HQ, Hong WK, Zheng RY. Eslicarbazepine acetate add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. No.: CD008907.

(8)Ping Yang*, Yi Wang, Jason A Wampfler, Dong Xie, Shawn M Stoddard, Jun She, David E Midthun, Trends in subpopulations at high risk for lung cancer. J Thorac Oncol, 2016, 11(2):194-202

(9)Huang R, Wei Y, Hung RJ, …, Wang Y, …, Christiani DC. Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium. EBioMedicine. 2015 Sep 24;2(11):1677-1685

(10)Taxiarchis V Kourelis, Ewa M Wysokinska, Yi Wang, Ping Yang, Aaron S Mansfield, Alfonso J Tafur*, Early venous thromboembolic events are associated with worse prognosis in patients with lung cancer, Lung Cancer, 2014,86(3):358-362

(11)Bo Deng, Stephen D. Cassivi, Mariza de Andrade, Francis C. Nichols, Victor F. Trastek, Yi Wang, Jason A. Wampfler, Shawn M. Stoddard, Dennis A. Wigle, Robert K. Shen, Mark S. Allen, Claude Deschamps, Ping Yang*, Clinical outcomes and changes in lung function after segmentectomy versus lobectomy for lung cancer cases, The Journal of Thoracic and Cardiovascular Surgery, 2014 ,148(4):1186-1192

(12)Jun She, Ping Yang, Yuqi Wang, Xinyu Qin, Jia Fan, Yi Wang, Guangsuo Gao, Guangxiong Luo, Kaixiang Ma, Baoyan Li, Caihua Li, Xiangdong Wang, Yuanlin Song, Chunxue Bai*, Chinese Water-Pipe Smoking and the Risk of COP,Chest,2014,146(4):924-31

(13)Ana I. Robles, Ping Yang, Jin Jen, Andrew C. McClary, Kara Calhoun, Elise D. Bowman, Kirsi Vahakangas, K. Leigh Greathouse, Yi Wang, Susan Olivo-Marston, Angela S. Wenzlaff, Bo Deng, Ann G. Schwartz, and Bríd M. Ryan*, A DRD1 Polymorphism Predisposes to Lung Cancer among Those Exposed to Secondhand Smoke during Childhood, Cancer Prev Res (Phila), 2014, 7(12):1210-8

(14)Zhifu Sun*, Liang Wang, Bruce W Eckloff, Bo Deng, Yi Wang, Jason A Wampfler, JinSung Jang, Eric DWieben,Jin Jen, Ming You and Ping Yang*, Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers, BMC Medical Genomics, 2014, 7:32

(15)Kulig K, Wang Y, Iyer S, Yang P. Predictive and Prognostic Value of ALK Gene Rearrangement in Non-Small Cell Lung Cancer. Epidemiology open access. 2014,4:1.

(16)Gang Chen, Wenjun Yang, Weidong Jin, Yi Wang, Chonglin Tao, Zhengping Yu*, Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells, Mol Biol Rep, 2012,39(10):9809-9815

(17)Chang XC, Yuan H, Wang Y, Xu HQ, Zheng RY. Eslicarbazepine acetate add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews. 2011 Dec 7; (12):CD008907.

(18)Gang Chen*, Yi Wang, Mengtao Zhou, Hongqi Shi, Zhengping Yu, Yefan Zhu, Fuxiang Yu. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma, Oncology Reports, 2010, 23(2):563-570

学术专著

(1)Zheng R, Tong Q, Wang X, Wang Y. Control and study of the first-time outbreak of angiostrongyliasis cantonensis in China, Chapter 14. In Li L, Zhan S (Eds): Epidemiological Research Cases in China. Beijing: People’s Medical Publishing House; 2008; 165-176.

(2)曾繁典；郑荣远；詹思延；杜晓曦；柏建岭；陈峰；…王怡….药物流行病学.第2版.北京：中国医药科技出版社；2016; 398-402.

同行评议审稿期刊

Journal of Thoracic Oncology

American Journal of Respiratory and Critical Care Medicine

Respirology

Lung Cancer

Journal of Thoracic Disease

Annals of American Thoracic Society

Oncotarget

Scientific Report