学历

博士

学位

博士

研究方向

头颈部癌的信号转导机制以及天然提取物的免疫功能性研究

所在学科

营养与食品卫生学

电子邮箱

m18744308309@163.com

简历

2010.09-2015.06

延边大学

预防医学/学士

2015.09-2021.03

韩国忠南大学

医学科学/硕、博士

2021.03-2021.08

韩国忠南大学

 博士后

2022.03-至今

温州医科大学

 讲师/第四层次引进人才

获得项目

发表文章

1. Jae Won Chang, Sung Tae Seo, Mi Ae Im, Ho-Ryun Won, Lihua Liu, Chan Oh, Yan Li Jin, Yudan Piao, Hae Jong Kim, Jung Tae Kim, Seung-Nam Jung, Bon Seok Koo.   Claudin-1 mediates progression by regulating EMT through AMPK/TGF-β   signaling in head and neck squamous cell carcinoma. Transl Res. 2022   Apr 21;S1931-5244(22)00071-8.

2.   Seung-Nam Jung, Chan Oh, Jae Won Chang, Lihua Liu, Mi Ae Lim, Yan Li Jin, Yudan Piao, Hae Jong Kim, Ho-Ryun Won, Seong Eun Lee, Min Joung Lee, Jun Young Heo, Sangmi Jun, Doheon Lee, Woo Seok Kang, Dae-Woong Kim, Ki-Sang Rha, Young Il Kim, Yea Eun Kang, Bon Seok Koo. EGR1/GADD45α Activation by ROS of Non-Thermal Plasma Mediates   Cell Death in Thyroid Carcinoma. Cancers (Basel). 2021 Jan 19;13(2):351.

3. Geonho Lee, Yea Eun   Kang, Chan Oh, Lihua Liu, Yanli Jin, Mi Ae Lim, Ho-Ryun Won, Jae Won   Chang, Bon Seok   Koo. Neuropilin-2   promotes growth and progression of papillary thyroid cancer cells. Auris   Nasus Larynx. 2020   Oct;47(5):870-880.

4. Yea Eun   Kang, Jin Man Kim, Mi Ae Lim, Seong Eun Lee, Shinae Yi, Jung Tae   Kim, Chan Oh, Lihua Liu, Yanli Jin, Seung-Nam   Jung, Ho-Ryun Won, Jae Won   Chang, Jeong Ho Lee, Hyun Jung   Kim, Hyun Yong   Koh, Sangmi Jun, Sun Wook   Cho, Minho Shong, Bon Seok   Koo. Growth   Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes   Thyroid Cancer Cells for Invasiveness. Thyroid. 2021 May;31(5):772-786.

5. Yanli Jin, SeuMi Ae Lim, Chan Oh, Yudan Piao, Hae Jong Kim, Lihua Liu, Yea Eun Kang, Jae Won Chang, Ho-Ryun Won, Kunho Song, Bon Seok Koo. Transcriptional   Regulation of GDF15 by EGR1 Promotes Head and Neck Cancer Progression through   a Positive Feedback Loop.Int   J Mol Sci. 2021   Oct 15;22(20):11151.

6. Lihua Liu, Mi Ae Lim, Seung-Nam   Jung, Chan Oh, Ho-Ryun Won, Yan Li Jin, Yudan Piao, Hae Jong Kim, Jae Won   Chang, Bon Seok   Koo. The effect of   Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in   head and neck cancer. Phytomedicine. 2021 Nov; 92:153758.

7. Chan Oh, Ho-Ryun Won, Woo Seok   Kang, Dae-Woong Kim, Seung-Nam   Jung, Mi Ae Im, Lihua Liu, Yan Li Jin, Yudan Piao, Hae Jong Kim, Yea Eun Kang, Min Joung   Lee, Jun Young   Heo, Sangmi Jun, Nam Suk Sim, Jeong Ho   Lee, Kunho Song, Young Il   Kim, Jae Won   Chang, Bon Seok   Koo. Head and Neck Cancer   Cell Death due to Mitochondrial Damage Induced by Reactive Oxygen Species   from Nonthermal Plasma-Activated Media: Based on Transcriptomic Analysis. Oxid   Med Cell Longev. 2021 Jul 6; 2021:9951712.

8.Seung-Nam Jung , Yea Eun   Kang , Gun Ho Lee, Lihua Liu, Chan Oh, Yan Li Jin, Mi Ae Lim, Kyungmin Lee, Taejeong Oh, Ho-Ryun Won, Jae Won   Chang, Bon Seok   Koo. Brn3a/Pou4f1   Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid   Cancer. J Clin Endocrinol Metab. 2020 Sep 1;105(9): dgaa316.

9. Ho-Ryun Won, Seung-Nam   Jung, Min-Kyung   Yeo, Shinae Yi, Lihua Liu, Mi Ae Lim, Chan Oh, Yea Eun   Kang, Jae Won   Chang, Ki Sang Rha, Bon Seok   Koo. Effect of Urban   Particulate Matter on Vocal Fold Fibrosis through the MAPK/NF-κB   Signaling Pathway. Int J Mol Sci. 2020 Sep 10;21(18):6643.

10. Kyungmin   Lee, Jae Won   Chang, Chan Oh, Lihua Liu, Seung-Nam   Jung, Ho-Ryun Won, Young Il   Kim, Ki-Sang Rha, Bon Seok   Koo. HOXB5 acts as an   oncogenic driver in head and neck squamous cell carcinoma via EGFR/Akt/Wnt/β-catenin   signaling axis. Eur J Surg Oncol. 2020 Jun;46(6):1066-1073.

11. Seung-Nam   Jung, Hyun Sil   Lim, Lihua Liu, Jae Won   Chang, Young Chang   Lim, Ki Sang Rha, Bon Seok   Koo.LAMB3 mediates   metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt   signals. Sci Rep. 2018 Feb 9;8(1):2718.

12. Yea Eun   Kang, Jung Tae   Kim, Mi Ae Lim, Chan Oh, Lihua Liu, Seung-Nam   Jung, Ho-Ryun Won, Kyungmin Lee, Jae Won   Chang, Hyon-Seung   Yi, Hyun Jin   Kim, Bon Jeong   Ku, Minho Shong, Bon Seok   Koo. Association between   Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer

Cancers (Basel). 2019 Aug 12;11(8):1154.

13. Jae Won   Chang, Ki Wan Park, Seung-Nam   Jung, Lihua Liu, Sung Min   Kim, Bon Seok   Koo. The most reliable   time point for intact parathyroid hormone measurement to predict   hypoparathyroidism after total thyroidectomy with central neck dissection to   treat papillary thyroid carcinoma: a prospective cohort study.

Eur Arch Otorhinolaryngol. 2020 Feb;277(2):549-558.

14. Jae Won   Chang, Ki Wan Park, Jae Hyung   Heo, Seung-Nam   Jung, Lihua Liu, Sung Min   Kim, In Sun Kwon, Bon Seok   Koo. Relationship Between 18 F-fluorodeoxyglucose   Accumulation and the BRAF V600E Mutation in Papillary Thyroid Cancer. World J Surg. 2018   Jan;42(1):114-122.

15. Lihua Liu, Chan Oh, Jae Hyung   Heo, Hee Sung   Park, Kyungmin Lee, Jae Won   Chang, Seung-Nam   Jung, Bon Seok   Koo. Clinical   significance of extrathyroidal extension according to primary tumor size in   papillary thyroid carcinoma. Eur J Surg Oncol. 2018 Nov;44(11):1754-1759.

16. Lihua Liu, Seung-Nam   Jung, Chan Oh, Kyungmin Lee, Ho-Ryun Won, Jae Won   Chang, Jin Man Kim, Bon Seok   Koo. LAMB3 is associated   with disease progression and cisplatin cytotoxic sensitivity in head and neck   squamous cell carcinoma. Eur J Surg Oncol. 2019 Mar;45(3):359-365.

17. Ji Su Park, Jae Won   Chang, Lihua Liu, Seung-Nam   Jung, Bon Seok   Koo. Clinical   implications of microscopic extrathyroidal extension in patients with   papillary thyroid carcinoma. Oral Oncol. 2017 Sep; 72:183-187.

18. Lihua Liu, Jae Won   Chang, Seung-Nam   Jung, Hee Sung Park, Taejeong Oh, Young Chang   Lim, Bon Seok   Koo. Clinical implications   of the extent of BRAF V600E alleles in patients with papillary thyroid carcinoma.   Oral Oncol. 2016   Nov; 62:72-77.

19. Jae Won   Chang, Seung-Nam   Jung, Ju-Hee Kim, Geun-Ae Shim, Hee Sung Park, Lihua Liu, Jin Man Kim, Jongsun Park, Bon Seok   Koo. Carboxyl-Terminal   Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck   Squamous Cell Carcinoma via Regulating Akt phosphorylation. Sci Rep. 2016   Jun 22; 6:28503.

20. Jae Won   Chang, Seo Young Gwak, Geun-Ae   Shim, Lihua Liu, Young Chang   Lim, Jin Man Kim, Min Gyu   Jung, Bon Seok   Koo. EZH2 is associated   with poor prognosis in head-and-neck squamous cell carcinoma via regulating   the epithelial-to-mesenchymal transition and chemosensitivity. Oral Oncol. 2016   Jan; 52:66-74.

21. Young Chang   Lim, Lihua Liu, Jae Won   Chang, Bon Seok   Koo. Lateral lymph node   recurrence after total thyroidectomy and central neck dissection in patients   with papillary thyroid cancer without clinical evidence of lateral neck   metastasis. Oral Oncol. 2016 Nov; 62:109-113.

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